Abstract :
Drug delivery using nanotechnology is showing progressive changes by playing a vital role in
developing new dosage forms. One of the technologies developed by using nanoforms is the vesicular drug
delivery system. Such advancement in nano-vesicular drug delivery is niosomes and proniosomes. Proniosomes
are a dry formulation of water-soluble carrier particles coated with surfactant and can be hydrated to form
niosomal dispersion immediately before use on brief agitation in hot aqueous media within minutes. Provesicular
systems, such as proniosomes which is one of the advancement in nanotechnology, minimize problems of the
vesicular system such as aggregation, fusion and leakage of drug and provide additional convenience in
transportation, distribution, storage and dosing. Conventional vesicular systems such as liposomes and niosomes
face stability related difficulty. This new emerging concept has demonstrated the potential in improving oral
bioavailability, targeting drugs to the specific site, It permeation of drugs across the stratum corneum. It prolongs
the existence of the drug in systemic circulation and finally reduces the toxicity.
Keyword :
Proniosomes, Niosomes, Transdermal, Coacervation.