Abstract :
The objective of the present work was to study the effect of different polymers on the solubility and dissolution rate
of ibuprofen a poorly water soluble NSAIDs, by spherically agglomeration using methanol, water and
dichloromethane as good solvent, poor solvent and bridging liquid, respectively. The quasi-emulsion solvent
diffusion technique was used as a method for spherical agglomeration. Spherical agglomeration of ibuprofen were
prepared by using polyethylene glycol-4000, polyethylene glycol-6000 and PVP k-30 as water soluble carries
proportions like 1:0.5,1:0.75,1:1. The agglomerates were subjected to various physicochemical evaluations such as
practical yield, drug content, solubility, flow properities, average particle size,scanning electron microscopy and
dissolution studies. The optical electron microscopy studies showed that the agglomerates posseeses a good
spherical shape. This study, demonstrated that the successful development of directly compressible spherical
agglomerates of ibuprofen prepared with hydrophilic polymers enhances the in-vitro dissolution property of
ibuprofen, whichcould provide rapid onset of action and potentially increases oral bioavailabilityThe dissolution
rate of Ibuprofen was found to be effected by nature of the superdisintegrant used in the preparation of tablets.
Based on the dissolution rate, superdisintegrants can be rated as SSG < Croscarmalose sodium < Crospovidone.
The formulation prepared with Crospovidone was offered relatively rapid release of Ibuprofen when compared with
other superdisintegrants used in this investigation.
Keywords: Ibuprofen, inflammation, Spherical Agglomerates, Emulsion solvent diffusion
Keyword :
Ibuprofen, inflammation, Spherical Agglomerates, Emulsion solvent diffusion