Abstract :
CMLis a clonal hematopoietic stem cell disorder. As per WHO classification,
CML is included in Myeloproliferative disorder. Adult type - CML is rare in
childhood constituting about 3% of childhood leukaemia. We have reported
such a case in a 7yr old male child. Peripheral blood smear and bone marrow
revealed features of chronic myeloproliferative disorder and cytogenetic
analysis has proved Ph chromosome positivity. We report one such case of
Philadelphia positive CMLin a 7 year old male patient with chief complaints
of fever on & off since 4-5 months and sense of abdominal fullness since 1
month, on examination pallor was found with mild hepatomegaly and
moderate splenomegaly. The clinical differential diagnosis was malaria,
storage disorder or tropical splenomegaly. Though biological behaviour and
prognosis are identical to that of adult type, we are reporting this case because
of its extremely uncommon incidence.
Keyword :
Chronic Myelogenous Leukaemia, Philadelphia positive CML, Clonal, Hematopoietic stem cell