Abstract :
The goal of this review is to comprehend existing methods for colon-targeting dosage forms that use microbially triggered (such as prodrugs and polysaccharide-based systems), pressure-dependent, pH-sensitive, osmotically controlled, and timed release systems. Over the past 20 years, colonic-focused drug transfer has become more and more significant due to the capacity to transfer therapeutic peptides and proteins as well as medications for the treatment of various colon disorders. With varying degrees of effectiveness, a sort of traditional approach that takes into account prodrugs, pH, time-dependent, and microflora-activated methods has been utilised in the past for colon-targeted delivery. Understanding current strategies for colon-targeting dosage forms that employ PH-sensitive, pressure-dependent, osmotically regulated, timed release, and microbially triggered (such as medicinal products and polysaccharide-based systems) systems is the aim of this review. Over the past 20 years, colon-focused drug delivery has become more significant due to its ability to administer medications for the treatment of numerous colonic disorders, as well as therapeutic peptides and proteins. A variety of traditional procedures, taking into account therapeutics, PH, time dependent on others, and microflora-activated, were all employed in previous years for colon-targeted dosing with varying degrees of success.
Keyword :
Colon, Drug Delivery, Anatomy & Physiology, Controlled Release