Abstract :
Osteoradionecrosis (ORN) is recognized as one of the most severe complications of radiation therapy. ORN is difficult to treat and often leads to poor outcome and deformity. Despite extensive literature documenting research and clinical experience, the underlying mechanism of ORN remains controversial. A better understanding of risk factors for the development of ORN and the underlying pathophysiology may improve our ability to prevent this complication and help to improve the prognosis for those being treated for ORN. A new theory for the pathogenesis of ORN has proposed that damage to bone is caused by radiation- induced fibrosis. Treatment protocols vary and include combinations of antibiotics, debridement, mandibulectomy, vascularised soft tissue and bone grafts, and hyperbaric oxygen therapy (HBO). This literature review highlights and discusses the pathophysiology, contemporary understanding, risk factors and numerous treatment options available.
Keyword :
Fibroatrophic theory, Microvasular free tissue transfer, Osteoradionecrosis, PENTACLO Treatment,