Abstract :
Chronic urticaria is a heterogenous skin condition. Second generation antihistamines are considered as first line treatment. In patients who do not respond to normal dose, second generation non-sedating antihistamines can be increased up to four fold. Some patients do not respond to higher dose of second generation non-sedating antihistamines. Omalizumab is an attractive option for such patients with chronic urticaria. However, cost of omalizumab is an important limiting factor for its wide use. Now with the availability of omalizumab biosimilar in India, it usage may be increased. We report two cases of difficult to treat chronic urticaria who responded to omalizumab biosimilar.
Keyword :
Biosimilar, Chronic urticaria, Omalizumab, Response.