Abstract :
Periodontal diseases are recognized as the major public health problem throughout the world affecting about 750
million people as on 2010. Periodontal diseases are group of infections and inflammatory conditions, including
gingivitis and periodontitis that affect teeth-supporting structures. A solution for these problems could be the local
administration of the drug formulated in a controlled release delivery system to be placed directly on the action site.
Ofloxacin is a synthetic fluorinated carboxy quinolone that has a broad spectrum of activity against both gramnegative
and gram-positive bacteria. Nine formulations of ofloxacin buccoadhesive tablets were prepared using
chitosan and co-polymers gaur gum, sodium alginate and HPMC K-15M. These tablets were evaluated by physical
parameters like thickness, hardness, % friability, weight variation, drug content, surface pH, buccoadhesive
strength, swelling index and In-vitro drug release. All the formulations showed compliance with pharmacopeial
standards, FTIR studies showed no evidence of interaction between ofloxacin and buccoadhesive polymers. Among
all the formulations F6 showed greater in-vitro drug release of 99.755 % in 8 hours and sufficient buccoadhesive
strength. The surface pH of all the formulations was found to be well within the limit of acceptable salivary pH
range. The results indicate that the buccoadhesive tablets of ofloxacin are good choice for treatment of periodontal
diseases.
Keyword :
Ofloxacin, chitosan, sodium alginate, mucoadhesion , In-vitro drug release