Abstract :
Renal cell carcinoma (RCC) is a spectrum of clinico-pathologically distinct entities thereby making it difficult to accurately predict the clinical outcome. Subjectivity and lack of reproducibility in nuclear grade mandates use of more objective parameters like nuclear morphometry. Out of 219 cases of RCC, nuclear grading was done in 181 cases and digital morphometry was done in 100 cases. Nuclear grade and morphometric parameters were correlated statistically with the clinical outcome of the patients. Histological nuclear grade did not show statistically significant correlation with progression free survival (PFS). Higher values of morphometric parameters were significant predictors of PFS with a strong inverse correlation. Nuclear morphometry is a more reliable predictor of clinical outcome in patients of RCC when compared to histological grade and should be included in predictive model with other clinical and pathological parameters to accurately determine tumor behaviour.
Keyword :
Renal cell carcinoma, Nuclear morphometry, Fuhrman nuclear grade.