Novel and efficient cytotoxic 2-alkyl, 4-chloro-5,6-dihydro-2h-pyran derivatives of aplysiapyranoids a-d,an anti solod tumer of human cells.


Volume :

5

Issue :

1

Abstract :

Cytotoxic 2-alkyl, 4- chloro-5, 6- dihydro-2H-pyran derivatives were first synthesized in single step method by using recyclable catalytic chloroaluminate immobilized in ionic liquids the reaction of aldehydes and ketones with homopropargylic alcohols using chloroaluminate ionic liquids generated the dihyropyran derivatives in good yields and with high stereoselectivity.
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