Abstract :
The spectrum of NAFLD ranges from mild steatosis to steatohepatitis with chances of progression to endstage liver disease and hepatocellular carcinoma. Prevalence of NAFLD varies in literature due to difference
in methodologies used by various investigators in the past.
This study was conducted in the department of Medicine and Pathology. This study was done to find out
the prevalence of hepatic steatosis in non-alcoholic asymptomatic adults, presenting with hepatomegaly
or unexplained elevation of liver enzymes with special reference to non-alcoholic steatohepatitis The
study also included study of prevalence of well-known risk factors like diabetes, dyslipidemia and obesity
associated with NAFLD in Indian population. This was a prospective study and cases were selected from
OPD and IPD by random selection, aged between 20 and 75 years, who presented with hepatomegaly along
with asymptomatic liver enzymes derangements or ultrasound suggestive of fatty liver in the absence of
history of alcohol intake. Out of 500 patients who agreed to participate in the study, 284 were males and
216 females. A total of 110 cases were found to have fatty liver on the basis of USG report, of which 75
cases were found attributed to NAFLD. Diabetes was seen in 32 cases out of these 75 patients, 43 subjects
had dyslipidemia, 48.67% cases showed elevated aminotransferases level. Liver biopsy was performed in 25
patients and 16% cases showed steatosis, 32% cases showed steatohepatitis and 4% cases showed cirrhosis.
Keyword :
Non-alcoholic fatty liver disease (NAFLD), Non-alcoholic steatohepatitis (NASH), Diabetes, Obesity, Dyslipidemia, Metabolic syndrome