Abstract :
Background: Liver disease in pregnancy has always been a challenging issue to an obstetrician. Early identification and aggressive management helps in reducing maternal and foetal morbidity and mortality due to liver diseases in pregnancy. An insight into aetiology of liver diseases in needed for better understanding, to combat its serious effects and reduce the impact of it.
Materials and Methods: This is an observational analytical study conducted at our hospital and data is collected from labour room admissions of department of obstetrics and gynaecology during March 2020 to May 2021.
Results: Out of 3737 cases admitted to labour room over a period of 15 months, 3638 cases (97.4%) were discharged healthy and 99 deaths (2.6%) were reported including both COVID and non-COVID cases. Out of 3638 cases, morbidity due to liver diseases was observed in 4.5% cases. Out of 99 deaths reported, 40 patients were COVID negative and 59 were COVID positive patients. Deaths due to liver disease were 12 (12.1%) out of all deaths reported. Out of 59 COVID positive deaths, liver disease was also a factor adding to the risk of mortality in 2 cases.
Conclusion: Early diagnosis and aggressive management is cornerstone for decreasing the risk of mortality and morbidity due to liver diseases. A multidisciplinary strategy with close collaboration between intensivists, hepatologists, and obstetricians is required for optimal therapy of liver illness in pregnancy.
Keyword :
Pregnancy liver, Maternal morbidity, Maternal mortality, COVID 19 in pregnancy, HELLP