Abstract :
Following the severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV), another highly pathogenic coronavirus named SARS-CoV-2 (previously known as 2019-nCoV) emerged in December 2019 in Wuhan, China, and rapidly spreads around the world.
Several recognized respiratory viral agents have a neuroinvasive capacity since they can spread from the respiratory tract to the Central Nervous System (CNS). Once there, infection of CNS cells (neurotropism) could lead to human health problems, because they are naturally neuroinvasive and neurotropic, human coronaviruses are suspected to participate in the development of neurological diseases.
Therefore, collecting new data will be instrumental to our understanding of how the ubiquitous human coronaviruses, given the proper susceptibility conditions and proper virus evolution and infection conditions, could participate in the induction or exacerbation of human neuropathologies. In the present study, we deduct the Severe Acute Respiratory Syndrome Coronavirus in the Brain.
Keyword :
Human coronavirus, Respiratory viral infection, Neuroinvasion, CNS infection, Neurological diseases.