Abstract :
A seizure in the neonatal period is an emergency that reflects potentially significant insults to the immature brain. Seizure represents the most distinctive signal of neurological disease in the newborn period and they are most frequent of the major manifestation of neonatal neurological disorder.
It is critical to recognise neonatal seizures, determine their etiology and to treat them promptly.
The neonatal period is one of high seizure hazard for a number of reasons. The last trimester and early neonatal period are characterized by rapid brain growth and development; both structure and function undergo substantial changes in relatively short time. This process has specific metabolic demand, substrate requirements and the need to proceed under relatively ideal conditions. Unfortunately the neonatal period is also characterised by a wide range of factors that can negatively impact this process; there are many diverse pathological process and disorders that may occur frequently and that may cause brain dysfunction. In addition the relative excitability of the immature brain compared with that of older children or adults make
the neonate more prone to seizure. As regards the aetiological factors in neonatal seizures they are many; some of them require multiple sophisticated investigations, while others can be diagnosed clinically with a few simple investigation. Thus in present perspective, neonatal seizure deserves intensive investigation and comprehensive research.
Keyword :
Neonatal seizure, Etiology, Research.