Abstract :
A novel series of 5-(4-formyl substituted phenoxy)-3-methyl-1-phenyl-1H-pyrazole-4-carbonitrile (1a-b) based
penta-substituted pyridine derivatives 4(a–n) was synthesized by piperidine catalyzed cyclocondensation reaction
through microwave. The newly synthesized compounds were characterized by spectral studies and also by C, H and
N analyses. The synthesized compounds were tested for their in vitro tuberculosis activity against H37Rv strains
using rifampicin, isoniazide and ethambutol as the standard drugs. All novel synthesized compounds were tested for
their in vitro antimalarial activity against P. falciparum strains using quinine and chloroquine as the standard
drugs. Molecular docking and pharmacokinetic study were carried out for all the targeted compounds.
Keywords: - antimalarial activity, antituberculosis, docking, microwave assisted, pyridine
Keyword :
antimalarial activity, antituberculosis, docking, microwave assisted, pyridine