Abstract :
Introduction: Chronic alcohol intake can lead to functional disturbances and irreversible lesions in organs such as the liver, brain, pancreas, gastrointestinal tract, heart, and endocrine gland. Determining the serum activities of various enzymes such as aminotransferases, glutamate dehydrogenase (GDH), and gamma-glutamyltransferase (GGT) has widely been used as a method of screening for hepatic involvement in chronic alcoholism.
Aim: This study was conducted to analyze multiple serum enzyme level changes in a chronic alcoholic with special reference to GGT and lipid peroxidase
Materials and Methods: 34 subjects were selected for the study. They are all male individuals with a positive history of chronic alcohol abuse. 10 healthy male volunteers who matched in age and socioeconomic status served as the controls.
Result : The activity of serum enzyme levels in test and control groups has been statistically analyzed. There was a highly significant difference (p
Conclusion: GGT can be taken as a marker of chronic alcoholism, provided serum bilirubin, SAP is within the reasonably average level
Keyword :
Alcoholic liver disease, Gamma Glutamyl Transferase (GGT), Serum Lipid Peroxidase, SGPT, SGOT