Abstract :
Introduction: Like any other Device associated infection, Ventilator Associated Pneumonia also poses
a great threat to public health. This study aims to know the prevalence rate of VAP and study the drug
resistance pattern of its causative agents.
Materials and Methods: A prospective, observational study involving 480 patients was conducted over a
period of twelve months to calculate the prevalance of VAP amongst the intubated patients and to isolate
the causative organisms with their resistance patterns for antibiotics.
Results: Among the 480 patients on mechanical ventilation included in this study, sixty patients developed
VAP. This amounted to a VAP rate of 31.25 per 1000 ventilator days. Culture yielded Gram negative
organisms in 51 samples and Gram positive cocci in 9, majority of which were multi drug resistant organism
by the virtue of producing ESBL, AmpC and MBL enzymes.
Conclusion: Identifying VAP and the MDR organisms causing it and formulating a tailored antibiotic
therapy is very imperative for the timely treatment and reduction in morbidity and mortality caused by
VAP.
Keyword :
VAP, ESBL, AmpC, MBL, MDR.