Abstract :
Background: A rise in Multidrug resistant causing ventilator-associated respiratory infections (VARIs) is posing a therapeutic challenge for physicians and diagnosticians worldwide. Timely detection and reporting of these robust multidrug resistant (MDR) pathogens would be useful in not only guiding an appropriate empirical therapy but also in controlling the spread of these drug resistant strains in the ICUs and hospital.
Objective: To detect in Endotracheal secretions of suspected cases of Ventilator-associated respiratory infections (VARIs) and report the antimicrobial sensitivity pattern for the same.
Study Design: Observational study conducted for a one year period in Department of Microbiology and ICU of tertiary care center for all suspected cases of VARIs above age of 18 years.
Result: The study showed that out of the 131 endotracheal samples received from suspected cases of VARI, was isolated among 29.6% (45). Monomicrobial growth was found in 39 and Polymicrobial growth in 6 samples. Almost all isolates were found to be multidrug resistant. Drug resistance was found against Penicillin, Cephalosporins, Piperacillin-tazobactam and Fluroquinolones. These MDR pathogens were found sensitive to Tigecycline (26%), Tetracycline (16%) and Ampicillin-sulbactam (11%).
Conclusion: MDR is a rising nosocomial pathogen commonly isolated from critically ill mechanically ventilated patients, timely detection of the same and reporting the drug sensitivity would ensure starting of an appropriate empirical therapy for management and a better prognosis for the patient.
Keyword :
MDR (Multidrug resistant), Ventilator-associated respiratory infections (VARIs)