Volume :
2
Issue :
2
Abstract :
The Hepatoprotective effects of Vitamins E and C (VEC) were evaluated in Carbon tetrachloride (CCl4) or Paracetamol (PC) induced hepatotoxicity in albino rats. Liver necrosis was induced by administering single dose of either carbon tetrachloride (CCl4, 1ml/k g, 50% v/v with olive oil, s.c.) or Paracetamol (PC, 1g/kg, p.o.). The liver damage was evidenced by Microscopic observation of Hepatic lobule configuration and the analysis of the levels of Serum glutamate oxaloacetate transaminase (SGOT), Serum glutamate pyruvate transaminase (SGPT), Serum alkaline phosphatase (ALP), Hepatic Thio-barbituric acid reacting substances (TBARS) and Superoxide dismutase (SOD) . VEC treatment (50/100 mg/kg Vitamin-E and 100/200 mg/kg Vitamin-C) by intraperitoneal injection, significantly (P