Volume :

4

Issue :

2

Abstract :

A validated RP-HPLC method has been developed for the determination of Domperidone maleate and Cinnarizine in tablet dosage form. This method is developed by using a Kromosil C18 column (250 cm length, 4.6 mm internal diameter and 5 µm particle size) and a mixture phosphate buffer pH 3.0, Acetonitrile and Methanol (40:40:20) as a mobile phase. The drug was quantified by a UV detector at 268nm. The method is linear for Domperidone maleate and Cinnarizine in range of 18 to 42 µg/ ml and 24 to 56 µg/ ml respectively. The Mean recovery of Domperidone maleate and Cinnarizine was found to be in the 99.73% to 99.23%. The Proposed method was found to be Linear, precise and accurate for the quantitative estimation of Domperidone maleate and Cinnarizine in tablets and can be used for commercial purposes.