Abstract :
Background: Dengue, endemic in India presents in mild to severe forms with or without bleeding. There
is no specific treatment available till date hence severe dengue has to be recognized in early stages. Platelet
counts are unreliable as they do not correlate with bleeding. Platelet indices have been studied for their
utility as predictors of severity of the disease and aid in guide to transfusion therapy. Mean platelet volume
is inexpensive and available with routine complete blood counts in hematology analyser. Its role as marker
in diagnosis, prognosis and treatment of dengue has been investigated with platelet indices reports.
Aims: To study MPV patterns, association with platelet counts and relevant laboratory parameters in
dengue.
Methods: The study was conducted over one month in the year 2016 in department of Hematology,
Kempegowda Institute of Medical Sciences Hospital, Bengaluru. 100 serologically proven dengue cases
were analysed with data collected from the records in the departments of Hematology and Microbiology
against patient’s unique hospital identification number.
Results: There was a predominance of young aged and male patients. The range for MPV was 8.7 – 13.2
(average 10.95) with 35% normal and 65% high MPV cases. There was 48% cases with moderately severe
/ severe thrombocytopenia. 32% with increased hematocrit, 35% with leucopenia, 54% with significant
atypical lymphocytosis and 42% with antibody pattern. There was an increased number of high MPV seen
in severe thrombocytopenia, increased hematocrit significant atypical lymphocytosis and antibody pattern
whereas normal pattern was noted in leucopenia.
Conclusion: High MPV is a useful predictor of severe dengue platelet recovery and may guide in
transfusion therapy.
Keyword :
MPV, Dengue, Platelet.