Abstract :
The human immunodeficiency virus (HIV) infects the immune system that leads to immune deficiency. Acquired
immunodeficiency syndrome (AIDS) is defined as the most advanced stages of HIV infection. It is defined by the
occurrence of any of more than 20 opportunistic infections or HIV-related cancers. According WHO and
UNAIDS estimation, 36.7 million people were living with HIV globally by the end of 2015. 2.1 million People
became newly infected, and 1.1 million died of HIV-related causes at the same year. HIV-1 protease plays a
vital role in the maturation of virus in order to produce the infectious viral particles. In this study, molecular
docking was performed on various imidazole derivatives by Autodock 4.2 into active sites of HIV-1 protease
(PDB ID: 4RVI)
Keyword :
Human immunodeficiency virus, HIV-1 Protease, 4RVI, Molecular Docking, Imidazole derivatives.