Abstract :
Microsphere of Enalapril malate were formulated by ionotropic gelation technique using like sodium alginate,
HPMC, carbopol 940, Guar gum, Xanthum gum in different ratios. Prepared micropeletes were evaluated for flow
behavior, drug entrapment efficiency, in-vitro dissolution and stability studies, including scanning electron
microscopy and optical microscopy. Of the ten formulations prepared and evaluated formulations F3 containing
HPMC 100 and carbopol found to show satisfactory results. The release of the drug from the micropeletes was
found to be following Non-Fickian diffusion, Drug diffusion coefficient and correlation coefficient were also
assessed by using various mathematical models. From the study it was concluded that prolonged release Enalapril
malate micropeletes can be achieved with success using ionotropic gelation technique.
Keyword :
Captopril , ACE inhibitor, anti-hypertensive, HPMC