Abstract :
Transungual drug delivery system is related with the drug delivery over the nail, which is hard because of presence
of keratin network into the nail. So in this review mainly concentrated on drug delivery over nail by using nail
lacquer formulations, which containing drug on it .The drug delivery via nail plate is done due to association of
several diseases into nail, for e.g. onychomycosis, psoriasis, paronychia, onycholysis .These nail diseases are
occurred due to presence of several microorganisms like- several fungi, bacteria, parasites and to cure these
diseases of nail, several medications should be used. Generally used medications are antifungals- fluconazole,
Itraconazole, butenafine, Clotrimazole and also used several antibiotics such as- ciprofloxacin, ofloxacin,
levofloxacin. There are several factors such as- Molecular size of the drug, hydrophilicity and lipophilicity of
diffusing molecule, nature of vehicle, formulation effect, which affected the delivery of drug over the nail plate. The
penetration of the drug molecules should be difficult so for the drug delivery use some penetration enhancers. In the
present review main focus on that delivery of drug is done by using formulation in the form of the nail lacquer.
Keywords: Medicated nail lacquers, Transungual, nail disorders, antifungals, antibacterials, Penetration
enhancers.
Keyword :
Medicated nail lacquers, Transungual, nail disorders, antifungals, antibacterials, Penetration enhancers.