Abstract :
Now a day’s problem in health has become more common. So, instead of curing them, prevention through dietary supplements has proven to be useful. In the case of patients who have already developed the disease at least relieving pain and suffer is a challenging thing. Arginine reduces the pain associated by synthesizing NO and causing vasodila-tion of blood vessels in sickle cell anaemia. Ornithine is converted to citrulline and finally to arginine through certain metabolic reactions like transamination. Arginine through NO regulates the endothelium of blood vessels and protects against trauma and ischemia. Arginine supplementation along with antioxidants proved to be useful due to additional protection offered during ischemia.
Keyword :
Sickle Cell Anaemia, L-Arginine, Ischemia, Glutamate, Vasodilation, Nitric Oxide