Abstract :
Background: Coagulase Negative Staphylococci (CoNS) have been recognized as an important agent of human infection since the past five decades. Significance of CoNS in human infection is increasing these days. CoNS are the indigenous flora of the skin and mucous membrane. They have long been considered as non pathogenic and were rarely reported to cause severe infections. However, as a result of the combination of increased use of intravascular devices and an increase in the number of hospitalized immunocompromised patients, CoNS have become the major cause of Nosocomial blood stream infections and they account for 9% of nosocomial infections.
Purpose: This study has been done to identify clinically significant CoNS associated with different human infections and also study their antibiotic susceptibility pattern isolated from clinical samples.
Materials and Methods : The present study was conducted in a teaching hospital of Punjab, India. A total 52 strains of CoNS isolated as a sole agent with a significant growth from various clinical samples were included in the study. The speciation of CoNS was done based gram staining, catalase test, coagulase test and VITEK – 2 Compact system.
Results: Out of 52 sample, 61.5% is male and 38.5% female coming. The most common CoNS species isolated were S. hemolyticus 28(54%), S. epidermitidis 8(15%), S.hominis 8(15%) and 8(15%).
Conclusions: The current study shown that pathogenic CoNS cause infection-related signs and symptoms. CoNS was discovered to be isolated from blood, urine, and pus, and S. hemolyticus, S. epidermitidis, S. homoinis, and S. saprophyticus were the most often found species in patients..
Keyword :
Blood stream infection, Staphylococcus hemolyticus, Staphyloccus saprophyticus