Abstract :
Purpose: To study the occurrence of pseudo endophthalmitis among patients undergoing intravitreal avastin (Bevacizumab) under various indications.
Materials and Methods: A retrospective analysis of case records of patients who developed an inflammatory reaction after Intravitreal avastin (Bevacizumab) was done.
Results: Eight of the twenty-Eight patients (28.5%) developed pseudo endophthalmitis. however, the repeated culture of aqueous or vitreous samples did not show any bacterial or fungal growth. all patients showed precipitation of drug in vitreous with the resolution of symptoms after 10 weeks of intensive oral and topical steroid treatment.
Conclusion: Intravitreal avastin (Bevacizumab) can result in pseudo endophthalmitis though it is a diagnosis of exclusion. given many complications, a larger clinical trial of intravitreal avastin (Bevacizumab) is needed to rationalize its use.
Keyword :
Avastin (Bevacizumab), Endophthalmitis, Intravitreal, Pseudo.