Abstract :
Background: Postoperative sore throat is a complication associated with endotracheal intubation. Many pharmacological
methods have been employed to treat and prevent it. Ketorolac has been shown to be effective for treatment of pain of
surgery. Here we have tried to study its efficacy in prevention of sore throat caused by endotracheal intubation. Methods:
With permission from the ethics committee, a double blind random study was conducted on forty consenting adult patients
of both sexes belonging to ASA I or II. They were divided into two groups K and C containing twenty each. Group K
patients were given Inj. Ketorolac intravenously 10 minutes before induction. Group C was the control group. Both the
groups were premedicated with Inj. Glycopyrrolate, Inj. Midazolam and Inj. Pentazocin; induced with Inj. Propofol and
intubated following Inj. Vecuronium. At the end of surgery muscle paralysis was reversed with Inj. Neostigmine combined
with Inj. Glycopyrrolate. The incidence of sore throat and severity were graded at 0,2,6 and 24 hours following recovery
from anaesthesia with the help of Verbal Rating Scale and statistical analysis was done. Results: Ketorolac decreases
post-intubation sore throat. Incidences of sore throat was 35% after extubation with Ketorolac premedication, which
decreased to 5% by 6 hours. Whereas the same was 80% and 45% respectively in the control group with 35% still
suffering from sore throat 24hrs post-operatively. The severity of sore throat ranged from mild to moderate in Group
K patients, but varied from mild to severe in the control group. Ketorolac premedication delayed the demand for postsurgery
rescue analgesia. Conclusion: Intravenous premedication with the anti-inflammatory drug Ketorolac tromethamine
can prevent sore throat induced by laryngoscopy and endo-tracheal intubation and delay post-surgical analgesic
requirements.
Keyword :
Postoperative sore throat, Ketorolac, Intravenous.