Abstract :
Introduction: Antibiotic resistance is a worldwide public health problem that requires urgent global
attention and Gram-negative bacilli of the Enterobacteriaceae family well known for demonstrate drug
resistance. These drug resistance microorganisms cause recurrent infections in patients in hospital units,
limiting treatment alternatives and increasing morbidity and mortality rates.
Material and Methods: A cross sectional study was carried out in the Department of Microbiology
Santosh Medical College and Hospital Ghaziabad. 150 Gram negative bacteria isolated from various
clinical samples from both IPD and OPD patients were included in this study.
Result: Among the Gram negative bacterial isolates maximum isolates were identified as E. coli (50%),
Klebsiella species (20%), Citrobacter species (12%), Pseudomonas aeruginosa (10%), Acinetobacter
species (07%) and Proteus species (04%). Enterobacteriacae isolate were sensitive to Imipenem (82.2%),
Gentamycin (55.5%), Cefepime (42.2%), and resistant to Ampicillin (85.9%), Ceftriaxone (82.9%) and
Levofloxacin (62.9%).
Conclusion: Routine surveillance of baseline resistance, expressing of hospital antibiotic policy and
compliance with current guidelines will go long way in reducing multi drug resistance among pathogen.
Keyword :
Gram negative, Antimicrobial.