Volume :

3

Issue :

4

Abstract :

The purpose of the present research was to formulate HPMC K4M based lamivudine transdermal patches and to study the influence of ethyl cellulose on its characteristics. TDDS formulations were prepared and characterized for the tensile strength, percentage elongation, water vapour transmission studies (WVT), water vapour absorption studies (WVA), FTIR, SEM, and in vitro drug release kinetics. The prepared patches showed good elasticity. The IR spectral studies showed that the drug remained in its normal form without undergoing any interaction with the polymers. The optimized formula based on drug release (F5) showed drug dissolution of 98.72% after 14 h.