Abstract :
Background: The resistance to antimicrobial agents among Staphylococci is an increasing problem. Clinical laboratories should perform D test routinely to guide the clinicians about the inducible clindamycin resistance and to prevent misuse of antibiotics.
Aims: Study aimed to isolates the Inducible and Constitutive clindamycin Resistance in Staphylococcus aureus in various clinical samples.
Materials and Methods: We analyzed the performance of disk diffusion method in 183 Staphylococci aureus strains obtained from various clinical samples of the patients collected from September 2018 to February 2020 at a tertiary care centre, Meerut.
Result: Inducible clindamycin resistance was tested by ‘D test’ as per CLSI guidelines. 142(77.6%) of S.aureus isolates were found to be methicillin resistant (MRSA) and 41 (22.4%) tested sensitive to cefoxitin i.e., methicillin sensitive S. aureus (MSSA).
Conclusion: Inducible resistance and constitutive resistance were found to be higher in MRSA as compared to MSSA). The D test method showed to be simple and easy in the detection of inducible (iMLSB) and constitutive clindamycin resistance (cMLSB).
Keyword :
Clindamycin, D test, Resistance, Staphylococcus aureus.