Abstract :
Dermatophytosis is one of the most common cutaneous fungal infections in India. Despite, quite a few
numbers of antifungal agents available for treatment, the resistance to antifungals by dermatophytes is
increasing day by day as seen by doctors in clinical practice. Itraconazole has shown good results in the
treatment of dermatophytosis at doses of 100 mg once a day for 2 weeks and with 200 mg once a day for
7 days. However, there are multiple itraconazole brands available in India. In this study, five different
itraconazole brands were evaluated in vitro for MIC values against clinical isolates of Trichophyton
mentagrophytes and Trichophyton rubrum by two different methods i.e. broth dilution and disc diffusion
tests. It was found that the Reference brand of itraconazole and the test brand of Itraconazole showed least
MIC values as compared to other available brands.
Keyword :
MIC, Itraconazole, Trichophyton mentagrophytes, Trichophyton rubrum broth dilution