Abstract :
With the use of the computer program PASS, we have predicted the anticonvulsant activity of chloral
carboxamides - products of chloral condensation with carboxylic acid amides. All connections, which structures
analysis being carried out, were obtained earlier, and the structures were taken from the SciFinder database. The
analysis of acute toxicity in rats has been carried out at intravenous and oral routes of administration using the
program GUSAR. Calculated LD50 values have been given for all structures. We have selected compounds leaders
tested for compliance with Lipinski criteria.
Keyword :
PASS, GUSAR, Anticonvulsant, Toxic, LD50, Chloral carboxamide