Abstract :
Schizophrenia is a chronic mental disorder affecting approximately 1% of the population. It is characterized
by the inability to think clearly, make decisions, and form social relationships with others. There are many
factors affecting the causation of this disease, but the serotonergic system and 5-hydroxytryptamine
receptors (HTRs) are most commonly associated with it. Three-dimensional structure of the protein
HTR 1A was built using Modeller 9.20 using crystal structure of the chimeric protein of 5-HT1B-BRIL
in complex with ergotamine (PSI Community Target) (PDB ID: 4IAR) as a template. The generated
model was validated using Ramachandran plot, which showed a model of good quality having 95.1%
of amino acid residues in the most favored region. Molecular docking studies also showed low binding
energy for all the compounds. Morusin exhibited the lowest binding energy of value ?8.52 K.cal/mol
while interacting with Ala289, Ser269, and Gly273.
Keyword :
Homology modeling, molecular docking, natural compounds, schizophrenia