Abstract :
Introduction: The extra nodal Non Hodgkin Lymphoma manifests in central nervous system as
Primary Central Nervous System Lymphoma (PCNSL) and is often co-existent with HIV AIDS and
other immunocompromised states. However, it has been gradually rising among the immunocompetent
individuals. As a highly infiltrative neoplasm, histopathological diagnosis is definitive. This study was
done to explore the Immuno Histochemical Profile in PCNSL.
Materials and Methods: This study was done as a case series by reviewing the specimens of 16 patients
with PCNSL who underwent treatment in the tertiary care centre for three years between 2010 and 2013.
After viewing H & E sections, slides were coated with chrome alum, and then treated by HRP (Horse radish
peroxidase) polymer technique.
Results: The mean age of the participants was 58.2 years. In three participants, the HIV status was not
known and the rest of the participants were HIV negative. Immunohistochemically the cells were positive
for LCA & CD 20, hence favouring the diagnosis of Non Hodgkins lymphoma B cell type.
Conclusion: Our study clearly elucidates the alarming trend in the incidence of PCNSL among
immunocompetent individuals. Moreover, the role of Ki-67 labelling and the definitive diagnosis by
immunohistochemical staining have been well established.
Keyword :
Central nervous system, HIV AIDS, Immunohistochemistry, Non hodgkin’s lymphoma, Primary central nervous system
lymphoma.