Abstract :
Background: Although, bacteria have been considered as most common cause of healthcare associated infections (HCAI), however recent years have witnessed increased isolation of fungal pathogens. species, Mucorales, spp., spp. and spp. are predominant fungal pathogens isolated from cases of HCAI. As compared to bacterial nosocomial infections, fungal infections are generally difficult to diagnose and treat. Nosocomial mycoses are associated with high mortality and morbidity. The present study was conducted in the tertiary care academic hospital with an aim to identify filamentous fungal pathogen isolated from HCAI and study its antifungal susceptibility profile.
Materials and Methods: Filamentous fungi isolated from cases of HCAI from intensive care unit (MICU) were included. They were identified by standard mycological techniques and antifungal susceptibility profile was studied.
Results: Out of 50 fungal pathogens, spp. were isolated from 21 (42%) cases, whereas 29 (58%) isolates were filamentous fungi. spp. (51.7%) were predominant among filamentous fungal pathogen. (27.6%) was the predominant isolate. Use of broad-spectrum antibiotics followed by neutropenia and presence of indwelling medical devices were common risk factors associated with HCAI due to filamentous fungi. Amphotericin B resistance was observed in 6.9% of isolates whereas 33.3% were resistant to fluconazole.
Conclusion: Invasive fungal infection (IFI) though less common is associated with increased morbidity and mortality in patients admitted to ICU. Neutropenia and use of broad spectrum antibiotics are important risk factors for IFI. is the most common filamentous fungus cause of IFI. More emphasis should be given on rapid diagnosis, prompt treatment and strict compliance with infection prevention and control practices.
Keyword :
Aspergillus spp, Amphotericin B, Filamentous fungi, Invasive fungal infection, Healthcare associated infection.