Abstract :
The aim of the present investigational work was to develop an in-situ gel system based on chitosan and poly
vinyl alcohol for ocular delivery of sparfloxacin. The hydrogel was developed by utilizing various concentration
of chitosan and poly vinyl alcohol. The prepared hydrogel was characterized for pH, tonicity, viscosity, swelling
and in-vitro drug release profile. Developed hydrogel underwent transition from solution to non-flowing
hydrogel upon getting change of pH. In-vitro release of drug was observed spectrophotometrically which was
upto 94% during six hours. The observed findings indicate that the proposed in-situ gelling system has
substantial potential as ocular drug delivery
Keyword :
In-situ gel system, Ocular delivery, Sparfloxacin, Chitosan, PVA.