Article PDF :

Veiw Full Text PDF

Article type :

Original Article

Author :

Debashis Mohapatra, Sunita Mishra

Volume :

7

Issue :

3

Abstract :

The ethanolic extract of leaves of Phyllanthus distichus results maximum yield value than that of petroleum ether extract, chloroform extract through successive extraction process. The ethanolic extract of leaves of Phyllanthus distichus showed maximum control in blood sugar in hyperglycemic wistar rats than other experimental extracts. The test extract also reduces the blood sugar level to a maximum extent in case of normal animals. Among the study of effects of alcoholic extracts of leaves of Phyllanthus distichus in both normoglycemic and hyperglycemic model through oral route. Toxicological study revealed that the alcoholic extracts Phyllanthus distichus leaves were safe and does not alter normal physiological and behavioral effect even at a higher dose level of 3000 mg/kg body weight. Administration of alcoholic extracts Phyllanthus distichus significantly reduces the elevated glucose level in alloxan induced diabetic rats confirms its anti-diabetic activity. This also reduces normal glucose level, which reveals the hypoglycemic property. The whole protein, whole cholesterol, ASAT, ALAT, ALP enzyme activity of alloxan administered rats showed significantly higher than normal rats, the test extract treated rats significantly reduced the elevated levels. The results of the present investigation indicate that the alcoholic extracts Phyllanthus Distichus leaves may have a place in the therapy of Diabetes Mellitus as anti-diabetic and/or hypoglycemic agent. The hypoglycemic and/or anti-diabetic effect of the test extract may be due to the influence on glycogenesis, glycogenolysis metabolic activity property of one or more of its constituents. Ethanolic extract of leaves of Phyllanthus Distichus is beneficial in lowering the blood sugar concentration and in the management of other diabetic complications without any doubt.