Abstract :
Purpose/Objective: Breast cancer occurs in any of the cells of the mammary gland and exhibits a wide
scope of morphological features, different immunohistochemical profiles, and unique histopathological
subtypes that have specific clinical course and outcome. This study was conducted to assess various
histomorphological variants of breast carcinoma.
Material and Methods: Total of fifteen cases of modified radical mastectomy specimens were
prospectively assessed from January 2019 to June 2019 in pathology department of Dr B.R. Ambedkar
Medical college and hospital, Bangalore.
Observation: Out of 15 cases, Invasive ductal carcinoma NOS was most common variant accounting
for 10 cases (66.66%) followed by 1 cases of Invasive Lobular Carcinoma breast, 1 case of Invasive
micropapillary carcinoma, 1 case of Medullary carcinoma, 1 case of Metaplastic breast carcinoma. The
histological grading of breast carcinoma was done on the basis of Elston – Ellis modification of Scarff -
Bloom - Richardson grading system. We found that Grade 2 tumours were more common accounting to 9
cases (60%) followed by Grade 1 tumour (26.66%).
Conclusion: This study emphasizes on the importance of assessment of histopathological variants of breast
carcinoma in not only in establishing the final diagnosis, but also in predicting the prognosis by histological
typing, staging and grading of breast carcinoma.
Keyword :
Breast carcinoma, MRM, Histomorphology, WHO, Staging, Grading.