Volume :
4
Issue :
2
Abstract :
The methanolic extraction of Hibiscus cannabinus Linn (MEHC) was pharmacological evaluation of Aflatoxin B1 (AFB1) induced hepatocellular carcinoma, AFB1causes oxidative stress and cellular the enhanced formation of reactive oxygen spices (ROS) and is associated with increases in biochemical parameters like serum glutamyl pyruvate transaminase (SGPT), serum glutamyl oxalacetic acid(SGOT), serum alkaline phosphatase (SALP), ã-glutamyl transpeptidase (GGT), bilirubin, lipid levels as well as decrease in the levels of total protein and uric acid. MEHC was administered orally (100 & 200 mg/kg) for 14 days to hepatocarcinoma bearing rats. The levels of lipid peroxides and activity of enzymic antioxidants leval were determined in liver homogenates. Marked increase in lipid peroxide levels and concomitant decrease in enzymic antioxidants levels were observed in carcinoma induced rats, while MEHC treatment reversed the conditions to near normal levels. Liver histopathology showed that MEHC reduced the Incidence of liver lesions, lymphocytic infiltrations and hepatic necrosis induced by AFB1 in rats. These results suggest that MEHC could protect liver against the AFB1-induced oxidative damage in rats, which may be due to its capability to induce the in vivo antioxidant system.