Abstract :
The hypolipidemic activity of Cassia tora (Chakvat, Chakunda) (Family: Caesalpiniaceae) seeds
extract has been studied in two hyperlipidemic models of rat. These are triton injected and
cholesterol rich HFD fed model of hyperlipidemia. In triton WR-1339 induced hyperlipidemia,
feeding with root extract (500 mg/ kg body wt/ day p.o. ) exerted lipid lowering effect as
assessed by reversal of plasma levels of total cholesterol (TC), phospholipids (PL), triglyceride
(TG) and reactivation of Post Heparin Lipolytic Activity (PHLA) of plasma. The other model
was fed with cholesterol rich HFD and seeds extract of Cassia tora (500 mg/ kg body wt/ day
p.o.) simultaneously for 30 days. This also caused lowering of lipid levels in plasma and liver
homogenate and reactivation of plasma post heparin lipolytic activity, hepatic total lipoprotein
lipase activity. The hypolipidemic activity of Cassia tora seeds was compared with a standard
drug guggulipid (200 mg/ kg body wt/ day p.o.), a known lipid lowering drug in both models.
Keyword :
Cassia tora seeds, Triton model of hyperlipidemia, Cholesterol rich HFD, Hypolipidemic agent, PHLA, Hepatic LPL activity, Hepatic steatosis.