Abstract :
Huntington gene is located on chromosome 4p16.3 IT15 locus considered a major causative gene of Huntington disorder. HTT is a neurodegenerative disorder mutation in gene cause abnormal movements and psychiatric disturbances. HTT is inherited in an autosomal dominant manner with almost complete penetrance and till now, no research studies provide insight into HTT gene. Bioinformatics analysis includes transcription factors binding sites, phylogenetic studies with reference to various selected orthologs and syntenic relationship of HTT gene. Our study showed that in HTT gene majority of the portion is conserved among two orthologs chimpanzee and mouse in significance to human. These studies also revealed information about conservation of genes among different ortholog species and their evolutionary relationship.
Keyword :
Huntington disorder, orthologs, CAG repeats, genome synteny analysis