Abstract :
Breast carcinoma is the most common tumor in women and it has resulted in significant morbidity and mortality. Recognition of tumor-associated antigens (TAA) by HLA class I-restricted CD8+ T cells is fundamental for the detection and destruction of malignant cells. HLA A24 has been shown to be associated with presenting peptides in breast carcinoma, which can be targeted for cancer immunotherapy. Overexpression of the HER2 receptor tyrosine kinase is associated with more advanced-stage disease at presentation and a rapidly progressive clinical course. Here we present a case of a 57-year-old female, who presented with a left breast lump. On histopathological examination, diagnosis of infiltrating ductal carcinoma was made . The patient had ER, PR negative and HER/neu positive cancer with nodal metastasis to supraclavicular lymph nodes. Course of Antracycline-based chemotherapy was started. Patient showed no signs of recurrence till the time of writing the article.
Keyword :
HLA A24, Breast cancer, HER2/neu, Infiltrating ductal carcinoma