Abstract :
There are several dosage forms in the market; there is a need for more dosage form which
acts effectively and locally as well as systematically. The benefits of the present research work is increased
retention time of the dosage form in oral cavity and increased bioavailability, reduction in gastric irritation by
passing first pass metabolism. Lollipops are flavored medicated dosage form intended to be sucked and held in the
mouth or pharynx containing one or more medicaments usually in the sweetened base. Medicated lollipop is
designed to improve patient compliance, acceptability. New drug design to this area always benefit for the patient,
physician and drug industry. The lollipops were prepared by heating and congealing method using
methylcellulose, citric acid as polymer. Oral thrush is a disorder caused by infection of the mouth due to the
fungus (yeast) Candida albicans. Lollipops containing antifungal medications can provide an attractive alternative
formulation in the treatment of oral thrush in pediatric patients. Clove oil and Ginger powder are used as an
antifungal drug. For patient’s acceptabilityweneedtoimprovethetasteofthedrugbyusingsugarsyrup.Pourability,
texture and elasticity is improved by using glycerin. It was found that the formulation containing
methylcelluloseandsugarsyrupshowedbetterdrugreleaseanditwasmorestable, unlike the other formulations. All the
formulations prepared were subjected to various physicochemical parameters like hardness, content uniformity,
friability, weight variationetc.
Keyword :
Lollipop, Plasticizers, Candida albicans, Oral thrush, Clove oil, Ginger