Abstract :
Diabetes is the most common metabolic disease of humans that its prevalence is increasing worldwide .The
status of antioxidants in the serum is one of the most important indicators for controlling and treatment of diabetes,
because it plays an important role in protection against oxygen species and oxidative stress .The purpose of this
study is to evaluate the serum levels of Glutathione and Malondialdehyde in type 2 diabetes mellitus with coronary
heart disease (T2DM-CHD) and comparing them to their levels in healthy individuals. Due to this reason, 50
cardiovascular patients effected by diabetes were studied over a period of two months, the blood samples of were
taken from healthy volunteers after 8 hours of fasting, and after centrifugation and separation of serum, biochemical
investigations conducted on the samples. The level of malondialdehyde serum in T2DM-CHD group was 19.32
±16.83 µM/mg-pr and and it increased significantly comparing with healthy group (6/93±3/33 µM/mg-pr). The
serum level of glutathione in diabetic group was 15/31±6/58 µM/mg-pr and it decreased significantly comparing
with healthy group (34.84±10/06 µM/mg-pr). The evaluation of malondialdehyde and reduction of glutathione in
T2DM-CHD decrease may play an important role in the developments of complications in these patients, therefore
the using of antioxidant as drug or supplement can probably decrease complications in T2DM-CHD.
Keyword :
Coronary Heart Disease, Diabetes, Malondialdehyde, Glutathione