Volume :

5

Issue :

2

Abstract :

The controlled gastric retention of solid dosage forms may be achieved by the mechanisms of mucoadhesion, flotation, sedimentation, expansion, modified shape systems, or by the simultaneous administration of pharmacological agent that delay gastric emptying. Based on these approaches, classification of floating drug delivery systems (FDDS) has been described in detail. Floating granules were prepared by using Direct Compression technique. The oral bioavailabilty of Labetolol has been reported to be about 25%. Gastric floating drug delivery is one approach where the gastro intestinal residence time is prolonged because of the floating behavior. In the present study the formulations were prepared by using different proportions of polymer. The prepared formulations were evaluated for different physicochemical characteristics such as thickness and diameter, drug content, weight variation, hardness, friability. The release characteristics of the formulation were studied in in-vitro conditions. The IR spectrum of pure drug and drug-polymer mixture revealed that there was no interaction between polymer and drug. The prepared floating tablet is industrially feasible method. Bulk density and tapped density shown good packability and Carr’s index results shown excellent compressibility. Formulation F16 containing combination of Metalose SR and Manucol was found to release a maximum of 97.2431% at the 12th hour.