Volume :
3
Issue :
1
Abstract :
Gastro retentive drug delivery system is one of the novel drug delivery system have lot of advantages. The various disadvantages of conventional oral dosage form can be successfully rectified by converting to this system. Ciprofloxacin is a broad spectrum antibiotic used commonly for the treatment of lower respiratory tract infection, H. Pylori infection and infectious diarrhea. Gastro retentive drug delivery system of ciprofloxacin fabricated to deliver the drug in a controlled manner. Fabrication done by incorporating drug with mixture of hydroxyl propyl methyl cellulose and sodium alginate as polymers and sodium bicarbonate, calcium carbonate as gas forming agents. Various evaluation parameters were undertaken to found out the ideal formulation. The various physico chemical and in vitro release studies for the system were done. Stability studies also conducted and revealed that the ideal formulation has adequate shelf life. Pharmacokinetic studies revealed the exact mechanism of drug permeation from the dosage form by diffusion. Thus the ideal formulation may be utilized for its controlled release in treating H.pylori infection.