Volume :

4

Issue :

4

Abstract :

In this study was to prepare fast disintegrating tablets of Celecoxib by using super disintegrants in varying proportions. The tablets were prepared by using various super disintegrants like crospovidone, cros carmellose sodium, explotab, magnesium sterate, talc and microcrystalline cellulose. The tablets were evaluated for weight variation, hardness, friability, wetting time, water absorption ratio, and disintegration time (DT) and dissolution study. From the results obtained, it can be concluded that the prepared tablets were shown good pre & post compression parameters and they passed all the quality control evaluation parameters as per I.P limits. Among all the formulations F3 formulation containing crospovidone as super disintegrant, showed maximum % drug release i.e., 99.8 % in 6 min hence it is considered as optimized formulation.