Volume :
2
Issue :
2
Abstract :
Matrix tablets containing Venlafaxine HCl were formulated by wet granulation method. Venlafaxine is a bicyclic antidepressant and is categorized as serotonin, nor epinephrine reuptake inhibitor. Because of its shorter biological half life (2-5h) and its high water solubility it was chosen to prepare sustained release matrix tablets. The individual and combined effects of matrix forming polymers i.e. HPMC and Sod CMC on sustained release were also investigated. All the pre compression parameters like angle of repose, Hausner ratio were found to be with in acceptable limits. It was found that concentration of polymer has influenced drug release from the tablets. Prepared tablets were evaluated for different quality control tests viz hardness, friability, thickness and drug content were with in the specified limits. The formulation containing the single polymer either HPMC or Sod CMC could not control the release of the drug effectively. But the formulation containing the combinations of HPMC and Sod CMC had shown better control over the release of the drug. Drug excipient compatibility was investigated using the method of Differential scanning calorimetry, FT IR spectroscopy, UV spectral analysis and the thermograms demonstrated stability and no interaction between the drug and the polymers and with other formulation excipients. The release data showed good correlation coefficient with Higuchi and Peppas kinetics. Stability analysis of best formulations were performed and showed no significant difference in drug content and release profiles. From the invitro evaluation it was observed that the tablets prepared by using combination of polymers give better controlled release for a period greater than 12 hrs.