Volume :

4

Issue :

4

Abstract :

The purpose of topical dosage form is to conveniently deliver drug across a localized area of the skin. To develop an ideal dosage form, one must take into account flux of the drug across the skin, nature of drugs, patient acceptability of the formulation, etc.., Nystatin is categorized as synthetic allylamine antifungal drug and is successfully used to treat Fungal disorders. On this contest, emulgel was formulated using carbopol 934 and HPMC, liquid paraffin as oil phase, emulsifying agents like tween 20 and span 20 and propylene glycol as permeation enhancersOn basis of quality of organogels produces total eight formulations F1 to F8 were selected. They were evaluated for physical appearance, pH, rheological study, spreadability, drug content and in-vitro drug permeation study. Thus, the formulated organogel had a distinct advantage over existing conventional dosage form in that the drug permeation was found to be rapid across the skin and hence the increased therapeutic response by bypassing 1st pass metabolism and with no gastrointestinal problems and patient compliance.