Volume :

4

Issue :

4

Abstract :

The aim of the present research work, Fenofibrate a BCS class II Anti hyperlipidemic drug belongs to fibrate class was formulated as solid dispersions by using various hydrophilic carriers to enhance the solubility, dissolution rate and oral bioavailability. Solvent evaporation method, Fusion Method and Melt Solvent method are used to prepare solid dispersions of fenofibrate. Solid state characterization of solid dispersions is done by Differential Scanning Calorimetry, Fourier-Transform Infrared spectrometry and X-ray powder Diffraction studies, Scanning electron microscopy. The solid dispersions can be evaluated by in-vitro dissolution studies. To develop the solid oral dosage form (Tablets) with fenofibrate solid dispersions. To study the physical parameters of tablets prepared by direct compression, which includes hardness, friability, weight variation, and disintegration. To estimate the % drug content in the solid dispersions and the fabricated formulations. To evaluate the drug release from the tablets by in-vitro dissolution studies and to compare in-vitro dissolution profile of fabricated formulation with marketed formulation.